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The nerves that transmit sensations from the chest to the brain can sometimes become compressed or inflamed, resulting in unusual feelings such as coldness or numbness

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These include uncertainties regarding optimal treatment duration, management of side effects, and the high cost associated with these medications

Some healthcare providers recommend tapering with lower doses before stopping completely

Estimated mean TMAO AUC, based on the linear mixed model, was 1,041 mol/L h for placebo and 1,048 mol/L h for pomegranate, with a (placebo/pomegranate) ratio of 0.993 (95% CI: 0.809, 1.22)

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