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The genetic causes of SCD include homozygosity for the rs334 mutation (HbSS, commonly referred as SCA) and compound heterozygosity between rs334 and mutations that lead to either other structural variants of -globin (such as HbC, causing HbSC) or reduced levels of -globin production as in -thalassemia (causing HbS/-thalassemia)

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In public statements following the filing, Hims called the lawsuit "a blatant attack by a Danish company on millions of Americans who rely on compounded medications for access to personalized care." Novo challenged the efficacy of Hims's oral formulation and cited its own testing of compounded semaglutide products, reporting impurity levels of up to 86% in injectable formulations and up to 75% in oral formulations