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GLP-1 agonists (Retatrutide, Tirzepatide, Semaglutide) create a caloric deficit primarily through appetite suppression

The off-period gives baseline NNMT activity a chance to reset before the next cycle

As a part of Dr Vidmars assessment she will always perform basic lab testing to insure proper selection of supplementation based on liver and renal function.

This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes