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This is the limitation of fenretinide, as it is hydrophobic in nature

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Traditional tanning methods, such as sunbathing and tanning beds, rely on UV rays to stimulate the production of melanin, the pigment responsible for the darkening of the skin

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As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication

mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins