Theres no clear understanding of why adequate levels of B12 are associated with a reduced risk of obesity, but there are a few theories 9-11 : B12 may influence how the body stores fat B12 is required for proper muscle protein, and low levels could interfere with recovery Insufficient B12 impairs red blood cell production and interferes with oxygen delivery to muscles Key takeaway: There is some evidence linking low B12 levels to a higher risk of obesity in children, adolescents, and adults, but the evidence is too weak to confirm a relationship
Accessed 2025.
Kempf, B
Measurements often go beyond the scale to include Body Mass Index, resting metabolic rate, and body composition, which provide a clearer picture of how the body uses energy
Hence, more investigations are needed to assess other signaling molecular pathways involved in MTX-induced intestinal injury to develop novel strategies for amelioration of intestinal injury induced by MTX
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