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DIO Gipr Syn/ and Glp1r Wnt1/ mouse studies Age-matched male Gipr fl/fl and Gipr Syn/ littermates were bred at Charles River Laboratories and shipped to Amgen at 79 weeks old, and age-matched Glp1r fl/fl and Glp1r Wnt1/ littermates were bred at Mount Sinai Hospital

1 unit 333 g | 7 units 2.33 mg | 10 units 3.33 mg

Funding : This work was supported by National Key R&D Program of China (Grant ID: 2023YFC3402800), National Science Fund for Distinguished Young Scholars (Grant ID: 82225025), National Natural Science Foundation of China (Grant IDs: 32171296, 32271351, and 32471435), Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars (Grant ID: 2024B1515020057), and China Postdoctoral Science Foundation (Grant IDs: 2023TQ0134, GZC20230968, and 2024M751117)

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