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Potassium-sparing diuretics, potassium supplements, and salt substitutes will increase the risk of hyperkalemia when used in combination with ACEIs and ARBs

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This means that a peptide with a 2-hour half-life administered three times daily will reach steady-state within approximately 10 hours, while a peptide with a 7-day half-life like Semaglutide requires roughly 35 days to reach steady state with weekly dosing