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As with all findings in this category, results are early-stage and not a basis for medical claims

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The SUMMIT trial (Packer et al, NEJM 2025) randomized 731 patients with HFpEF and obesity (mean BMI 38) to tirzepatide vs

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Drugs-induced increased expression of GSH could play an important role in the protection against the toxic effects of AFB1 12

While mutations in the drug target are involved in the resistance to many molecularly targeted agents [164], mutations in IGF-IR are barely detected in cancer cells resistant to anti-IGF-IR agents