1 H Diffusion-ordered spectroscopy (DOSY) NMR The NMR samples for 1 H DOSY NMR spectroscopy were prepared in 0.3 mL CDCl 3 or D 2 O at 298 K and recorded with solvent-matched Shigemi NMR tubes (Wilmad CMS-005B for CDCl 3 and BMS-005B for D 2 O) to minimize convection
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Drug-drug interactions are minimal given predominant non-renal, non-hepatic elimination pathways, though delayed gastric emptying may affect absorption of oral medications with narrow therapeutic windows
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