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If trial results are positive, Eli Lilly could submit for FDA approval as early as 2025-2026, with potential commercial availability following approval

DOI: 10.1001/jama.2025.24288

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The higher doses slow gastric emptying, which can cause discomfort as the stomach remains fuller for extended periods, leading to vomiting

External appeals have a higher overturn rate, particularly when clinical justification beyond BMI alone is strong (cardiovascular indication, sleep apnea documented by sleep study, or other comorbidities)