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Funding This study was supported by the National Institute of Hospital Administration, National Health Commission Project of China (Grant number 23H1110)

[15] Mechanism of action [edit] Upon binding to its ligand GLP-1, the GLP-1 receptor activates intracellular signaling pathways that regulate insulin secretion, glucose metabolism, and satiety

Conclusion We found that compared with dulaglutide therapy, injectable semaglutide therapy could exhibit better efficacy in ameliorating oxidative stress and glucose metabolism, including daily glucose variability, in patients with T2DM, while dulaglutide therapy may be better in improving treatment satisfaction as evaluated via DTSQ scoring