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Most experts believe that migraine aura is caused by a phenomena in the brain called cortical spreading depression (CSD), a slowly progressing wave of excitability followed by long-lasting neuronal inhibition (Bogdanov 2011a)

While this seems counterintuitive (you might expect less side effects from weaker medication), degraded peptides with altered structures can sometimes trigger different inflammatory responses at the injection site

During your initial visit and history review, our team confirms that B12 therapy is appropriate for you

Saline (0.9% sodium chloride) is another option sometimes mentioned, but it can occasionally cause peptide aggregation or affect solubility, depending on the specific amino acid sequence

Perdikari, A

Yes, B12 injections may have had a moment in the spotlight, but it's not really advisable (or necessary) for the average person, Keatley says