DPP-4 inhibitors are generally well tolerated, with a low risk of contributing to hypoglycemia when used as monotherapy or in combination with metformin due to their glucose-dependent mechanism of action
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However, this dependency is likely not universal and a systematic understanding of how different oncogenic drivers rewire autophagic networks remains to be elucidated
For example, fusion proteins and RNA therapies can achieve extended half-lives or sustained protein production, reducing the dosing frequency and improving patient compliance
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