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doi: 10.1038/s41594-023-01134-0 28 HeerspinkHJLPerkinsBAFitchettDHHusainMCherneyDZI
Some metabolic enzymes, such as succinate dehydrogenase (SDH), fumarate hydratase (FH), IDH and pyruvate kinase 2 (PKM2) are likely to activate HIF-1 pathway by stabilizing HIF-1, therefore enhancing cancer metastasis (258)