DISSECTION P938 - ESOC25-2421 CADASIL Argentine Registry (CADASILar): Establishing a Harmonized Clinical Protocol preliminary data Julieta Rosales 1 , Carolina Ardohain 2 , Juan Lopez 3 , Fabio Gonzalez 4 , Julian Alonso 5 , Valentin Selvaggi 6 , Diana Cristalli 7 , Ismael Calandri 2 1 Clinica Sagrada Familia-ENERI, Buenos Aires, Argentina, 2 FLENI, Buenos Aires, Argentina, 3 Sanatorio Los Arcos, Buenos Aires, Argentina, 4 Hospital Italiano de Bs As, Buenos Aires, Argentina, 5 Hospital Posadas, Buenos Aires, Argentina, 6 Hospital Ramos Meja, Buenos Aires, Argentina, 7 Centro Jesi, Buenos Aires, Argentina Background and Aims: CADASIL, a leading monogenic small vessel disease caused by NOTCH3 mutations, manifests with migraines, strokes, and cognitive decline
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The result is a market in which sophisticated-sounding molecules have become available far faster than scientists can determine what they actually do
But here is the reality I keep seeing in the field: Many wastewater plants already meet their discharge consents perfectly well, yet still fall short of what is needed for safe and reliable reuse, especially when micropollutants such as pharmaceuticals and personal care products enter the conversation
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Initial correction of significant deficiency typically involves weekly or biweekly injections for several weeks until levels normalize and symptoms resolve
