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This is believed to explain the unprecedented magnitude of weight reduction observed in Phase 2 clinical trials

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At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice (Eagleson et al., 2013)

Given the lack of serious AEs and the possibility that the medication may benefit a subset of patients, the administration of oral hydroxyzine was designated as an Option

Either the peptide needs a different solvent (like acetic acid water) or it's degraded