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doi: 10.1002/prca.201600169 60 HeLWongCKCheungKKYauHCFuAZhaoHLet al

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Additional investigations may include ECG to exclude cardiac arrhythmias, blood tests to rule out anaemia or thyroid dysfunction, and assessment for conditions that can mimic or coexist with POTS

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For example, manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, can undergo nitration of its tyrosine residues, leading to enzyme inactivation and contributing to oxidative stress and related diseases

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Both OA and RA target joints and can lead to their progressive disability, which is a burden not only on affected individuals but also on the healthcare system

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