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Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, et al

A study in 650 elderly men and women reported that the risk of elevated plasma homocysteine levels was significantly higher in those with lower cognitive function scores (72)

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The primary endpoint is change in the CDR Sum of Boxes score at week 104

To this end, Auranofin (an efficient inhibitor of thioredoxin reductase) is being evaluated in multiple clinical studies