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Without access to the underlying clinical data from the VA program referenced in the title, including sample size, primary and secondary endpoints, baseline characteristics, and reported outcomes with confidence intervals or p-values, a clinically accurate summary cannot be produced

Elevated ROS within the adipose tissue triggers lipid peroxidation [45] and accumulation of reactive aldehydes including the bioactive lipid peroxidation product 4-hydroxynonenal (4-HNE) [90]

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The focus instead is placed on bridging mechanistic views with those of translational perspectives

1 2 PDB: 1Q0M