The glycocalyx on the endothelial cell surface regulates cell adhesion, anticoagulation, vascular permeability, mechanoreception, and mechanotransduction [8, 9]
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This is particularly important in times of stress or disease, as it ensures that the immune system can effectively defend the body
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In a recent study by Gong et al., nanoparticles delivering an inhibitor of sphingosine-1 phosphate receptor-1 dramatically inhibited TNBC growth and angiogenesis in vivo via downregulating STAT3/VEGF axis (Gong et al., 2021)