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Using a yeast interaction network (The Cell Map 27 ), we identified GSH1 and GSH2 (yeast glutamylcysteine ligase and glutathione synthetase, respectively) as two of the highest scoring synthetic lethal interactions of mtm1, the S.cereviase ortholog for SLC25A39 (p-value=2.78E-28 (GSH1)
599 Ndfip1 overexpression may restore mitochondrial dysfunction in PD mice by regulating voltage-dependent anion-selective channels
PMC 6641943
Engin AB, Engin ED, Engin A
It appears to modulate neurotransmitter systems, including dopamine and serotonin, and has shown efficacy in counteracting damage induced by various neurotoxins, suggesting potential applications in neurological conditions like Parkinson's disease and schizophrenia-like models
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