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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)

Liu R-M, Desai LP

Yokosho et al., 2010)

Approximately 50% of HMBi is shielded from ruminal degradation, with the remaining 50% undergoing hydrolysis by rumen microorganisms to HMB and isopropanol (Graulet et al., 2005)

This observation means that xCT blockage induces the accumulation of glutamate that is converted into -ketoglutarate instead of being used in glutamate-cysteine exchange and consequently that is why cysteine does not enter the cell and give rise to glutathione