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(125) further studied DHEA-induced PCOS rats and suggested that berberines regulatory mechanism may involve cell apoptosis and the regulation of key signaling molecules, such as TLR4, LYN, PI3K, AKT, NF-B, TNF- , IL-1, and IL-6, and caspase-3 expression

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ETV6 knockdown significantly inhibited PDO growth, supporting the role of ETV6 in driving EC proliferation (Figure S4B, C)

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Hepatic fatty acid oxidation: GCGR activation in the liver promotes fatty acid -oxidation, increasing the rate at which the liver metabolises stored fatty acids contributing to lipid management that complements the reduced lipid intake driven by appetite suppression

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