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These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) What should you not do after a B12 shot

A GRAS determination reflects a safety conclusion for a described food-ingredient use and is not equivalent to drug approval or a finding of therapeutic efficacy

5-Amino-1MQ injection should be administered subcutaneously (under the skin) using a 29-31 gauge insulin syringe

Before treatment, potential benefits, risks, and possible side effects are discussed to support informed decision-making

10.1093/milmed/163.6.434 Mil Med