J Pharmacol Exp Ther 268 : 15711580
Curr Neurovasc Res 18(1):134149 Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA (2018) OLT1177, a -sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
We hypothesize that CstB evolved this mechanism to prevent the release of toxic sulfite, which interferes with the homeostasis of low molecular weight thiol homeostasis, impairing cellular antioxidant defenses 42
Simple, boring, effective
It introduces skin flora, airborne particles, and whatever else it touched directly into your supposedly sterile solution
Picture shown is for illustration purpose only