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First, the instances of Semaglutide (Ozempic) causing thyroid cancer were recorded with animals (rats, to be precise)

Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia LM, Lewis DA et al (2006)

But that approval came after specific pediatric trials

(5) Studies have shown that IGF-DES activates the IGF-1R with similar affinity to native IGF-1, triggering receptor autophosphorylation and activation of the PI3K/AKT and MAPK/ERK pathways

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