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[1] The honest summary is that the animal record is heterogeneous: some biomarkers move favorably in some strains and protocols, but a clean, reproducible, cross-laboratory lifespan-extension signal is not established, and the variability across experiments is itself a reason for caution rather than a footnote to be skipped

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Rappsilber, J., Ishihama, Y

ROS-induced cellular stress can lead to misfolded and damaged organelles, prompting cells to activate autophagy to eliminate these harmful components and restore homeostasis [166, 167]

It has some human skin data that is encouraging

What Most GHK-Cu Pages Get Wrong This is the section commodity pages skip entirely