This distinction has clinical significance for safety and therapeutic consistency
Breast Cancer Outcomes and Study Limits In sum, GLP-1RAs were associated with improved all-cause mortality and RFS among adult female BC patients with obesity compared with non-use, and among those with T2D compared with insulin/metformin, while comparisons with SGLT2 inhibitors were less consistent
These medications may not be suitable if you have severe gastroparesis, active eating disorders, extreme frailty with low BMI, or very limited life expectancy
B12 deficiency can cause: If you have anaemia caused by a vitamin B12 deficiency, you may have other symptoms, such as: Some of these symptoms can also happen in people who have a vitamin B12 deficiency but have not developed anaemia
However, a comprehensive review published in 2025 emphasized that the majority of this evidence remains preclinical , meaning it was not conducted in large, well-controlled human trials
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