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The key detoxication enzyme is MerA, the mercuric ion reductase, and also a second enzyme, MerB, is present in the gene cassette, and its activity is to split the carbon-Hg bond in organomercurials such as the potent, naturally occurring neurotoxic agent methylmercury chloride and the synthetic chemical disinfectant phenylmercuric acetate [89,90,91]

Selenium directly affects GPX4 activity and cell sensitivity to ferroptosis (24)

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