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Reduced-dose maintenance is better supported than complete withdrawal, but the exact interval remains uncertain

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The multinational MariTide phase 2 obesity trial evaluated the efficacy and safety of MariTide at doses from 140 to 420 mg with or without escalation over 52 weeks, in adults with obesity with or without diabetes [35]

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It identified semaglutide-associated suicidal ideation remained significant when compared with dapagliflozin and metformin, and in the sub-group of patients with co-reported use of antidepressants and benzodiazepines