how was semaglutide discovered Redefining peptide therapeutics with Discovery and Invention of Semaglutide

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[21] Karmashetty, V., Acharya, J.D., Ghaskadbi, S., Goei, P

Researchers found that patients taking GLP-1 receptor agonists had reduced risk for 10 out of 13 obesity-associated cancers compared to those taking insulin: Cancers with Significant Risk Reduction: Gallbladder cancer (65% risk reduction) Pancreatic cancer (59% risk reduction) Colorectal cancer (46% risk reduction) Esophageal cancer (reduced risk) Endometrial cancer (reduced risk) Kidney, liver, and ovarian cancers (reduced risk) Multiple myeloma and meningioma (reduced risk) Impressive Real-World Impact Perhaps most striking were findings presented at the 2024 American Society of Clinical Oncology (ASCO) meeting

When semaglutide appears to not work, the issue is almost never the medication

Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R