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Despite this potential, given the known long-term benefit of lowering hemoglobin A1c in preventing DR progression, there does not appear to be any contraindication to initiating GLP-1/GIP agonist therapy with appropriate ocular monitoring

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in 1984 of leptin (45), a peripheral active appetite inhibiting hormone produced by adipocytes and acting both via specific receptor (Ob-R) on afferent vagal nerves and directly on ARC neurons enhancing satiety, raised a hope in progress in obesity therapy (44)

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