BioDrugs 34 , 567586 (2020)
Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD
Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, et al
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Compounders can still make alternative versions of the drugs if they modify doses, add other ingredients, or change the route of administration in compliance with FDA rules
Fifth, regulatory and reimbursement varies across countries and regions, affecting its widespread implementation (148)