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Yet another aspect of the invention is to provide a method for treating patients not responsive to a PDE-5 inhibitor alone, the method including administering both PT-141 and a PDE-5 inhibitor, wherein the PDE-5 inhibitor is administered prior to administration of PT-141

Lingvay, I., Desouza, C

Ex vivo rectal tumour samples more accurately reflect the dynamic tumour microenvironment, the complex architecture of the tumour, and the inherent genetic diversity between patients and therefore, this data supports metformin as a metabolic modulator in rectal tumours