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DOI: 10.1016/j.scitotenv.2023.161892

There are six binding proteins, each with a different affinity for IGF-1

In addition, degradation within the gastrointestinal tract and first-pass metabolism substantially reduce systemic bioavailability, and preclinical animal findings may not consistently predict human pharmacokinetics and efficacy ( in vivo transformation mechanisms to meet the stringent demands for safety, stability, reproducibility, and standardization necessary for clinical translation

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However, more human studies are needed to confirm these findings (7)

Caffeine Caffeine is a popular and highly consumed food ingredient found in coffee, tea, chocolate, cocoa, some medicines, and dietary supplements (216)