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Storage: Store at 2-8C

A weakened glycocalyx can further increase the risk of gut dysbiosis (see Histamine test)

Furthermore, due to deficient GH secretion, the ability of GH to antagonize the anti-lipolytic effect of insulin is reduced, leading to accumulation of visceral adipose tissue (VAT)

With Creatine

Protein-rich foods and certain bioactive compounds may increase postprandial GLP-1 secretion, though effects are modest compared to pharmaceutical GLP-1 agonists

Patients should also clarify emergency protocols: whom to contact if symptoms worsen, when to seek urgent care, and criteria for temporarily holding semaglutide (such as during severe gastrointestinal symptoms, dehydration, or hospitalization)