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13,20 Discussion The dermatosparaxis type of EDS is a rare but severe autosomal recessive heritable connective-tissue disorder resulting from disturbed processing of type I procollagen N-propeptide due to biallelic loss-of-function mutations in ADAMTS2 encoding the most important type I procollagen N-endopeptidase

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Generational differences are also shaping expectations in powerful ways

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All authors contributed to the discussion and read and approved the final version of the manuscript