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Liraglutide 1.8 mg and semaglutide 2.4 mg are established GLP1-RAs for obesity treatment

In pre-marketing clinical studies of brand-name Wellbutrin SR (sustained-release bupropion) in the treatment of major depressive disorder, mild weight loss of greater than five pounds occurred in 28% of all patients receiving the medication at either a dose of 300 mg per day or 400 mg per day

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker: It plays well with most ingredients and is typically used at 0.1-1%

However, these inconsistencies may be due to variations in disease chronicity, age, and symptom severity among study participants

By identifying the gut microbiome as an active player in the effects mediated by GLP-1 instead of a mere passive factor, this review puts forth a conceptual framework designed to clarify the variability in therapeutic responses and to inform the creation of personalized GLP-1 strategies that take the microbiome into account