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Immunohistochemical staining and western blot analysis revealed that SNL increased the activation of microglia and astrocytes in the dentate gyrus of the hippocampus, along with elevated expression of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which were significantly reversed by exendin-4 treatment [68]

These proteins showed enrichment in GO_MF terms related to catalytic activity (299 proteins, 53%) ( p adjusted = 2.7E-14) and hydrolase activity ( p adjusted = 4.3E-14) (Supplementary Table S6