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Beyond weight loss: the disease-modifying potential of GLP-1s Mike Haney: So mechanistically it sounds like the outcome is the same as what we would be trying to achieve with lifestyle which is essentially negative energy balance

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Integration Of Dual GLP-1/GIP Agonist To Enhance Weight-Loss Efficacy In Obesity Treatment Major companies in the GLP-1 receptor agonist market are focusing on the integration of dual GLP-1/GIP agonist therapies designed to deliver greater weight-loss efficacy and broader metabolic benefits compared to traditional single-pathway treatments

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In a double-blind, multinational phase IIb clinical trial, 556 patients with well-controlled diabetes and high cardiovascular risk were randomly assigned to receive subcutaneous placebo or canakinumab [324]