Scientific Background Small-molecule metabolic regulators are widely used in research exploring enzymatic signaling pathways
PubMed Willard, F.S., Douros, J.D., Gabe, M.B., Showalter, A.D., Wainscott, D.B., Suter, T.M., Capozzi, M.E., van der Velden, W.J., Stutsman, C., Cardona, G.R., Urva, S., Emmerson, P.J., Holst, J.J., DAlessio, D.A., Coghlan, M.P., Rosenkilde, M.M., Campbell, J.E., & Sloop, K.W
W., & Talalay, P
Glycosylation of the AMPK- subunit inhibits AMPK function, and arginine treatment protects AMPK- from glycosylation and increases AMPK phosphorylation in a mouse model of AD, thereby ameliorating AD disease
Kurze Wege, volle Kontrolle
gastrointestinal side effects and dose-dependent tolerability issues were the most notable findings, and Phase 3 trials are needed before regulatory submission