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While the potential cost of authorizing Medicare coverage of anti-obesity drugs has presented a barrier to enacting legislation to lift the prohibition, covering these drugs under Medicare for authorized uses has already catapulted these drugs to rank among the top-selling drugs covered by Part D, Medicares outpatient drug benefit program

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GLP-1 receptor agonists are synthetic analogs or modified versions of this endogenous hormone, designed to resist degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), thereby extending their duration of action from minutes to hours or days