The balance between ACE and ACE2 activity influences the ultimate effect of RAAS, since ANG II promotes vasoconstriction and proliferation while ANG (1,7) stimulates vasodilation and apoptosis ( Recently, three new axes have been identified, emphasizing the role of the kidney in this picture ( The ACE2/ANG(1-7)/Mas receptor pathway ( The prorenin/PRR/MAP kinases ERK1/2 axis: in the past years, renin was considered simply as an enzyme catalyzing the conversion of AGT into ANG I
T.KalkumM.et al (2020)
History of bowel obstruction or ileus Slowed motility may increase risk in susceptible individuals
From a mechanistic perspective, GLP-1 appears to facilitate the differentiation of regulatory T cells (Tregs) while simultaneously inhibiting the responses of T helper 1 (Th1) cells and Th17 cells, both of which play a significant role in the pathogenesis of RA
however, as noted earlier, findings have not yet been published
Red flags that a GLP-1 provider isn't doing right by you Dr
