Weight loss, particularly rapid weight loss often seen with these drugs, inevitably involves the loss of both fat mass and lean body mass (muscle)
Once insulin therapy is initiated, patients are infrequently titrated off this regimen, even when newer medications with additional benefits become available
Programs like TrimrX that utilize compounded GLP-1s are designed as a direct-pay, cash-based alternative to the insurance system
However, clinicians should remain vigilant for signs of excessive metabolic suppression or thyroid dysfunction, particularly in patients with pre-existing thyroid conditions or those experiencing symptoms beyond cold intolerance, such as severe fatigue, hair loss, or cognitive changes that might suggest thyroid hormone imbalance requiring investigation
Salinas A, Merino PM, Giraudo F, Codner E
One mouse in vehicle group was excluded from analysis due to sickness