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The interaction between systems creates a potential positive feedback loop through signaling molecules such as ROS, DAMPs, cytokines, and metabolites, potentially explaining the delayed onset, persistence, and multi-system nature of the symptoms

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In plants exposed to temperature extremes, heavy metal-contaminated soils, drought, or air pollutants, the generation of reactive oxygen species and alterations in the intracellular redox environment perturb cellular physiology (Ogawa, 2005)

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