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Oncogene (2013) 32(26):31118.10.1038/onc.2012.435 154 MelmedSPolonskyKSLarsenPRKronenbergH

Compared to placebo, the treatment with intramuscular acetyl-l-carnitine significantly reduced weekly mean pain on the VAS, whilst during the open-label part of the study, oral acetyl-l-carnitine improved symptoms in the entire cohort, with no safety issues [81] (Table 2)

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Anomanolide C (AC), a natural withanolide isolated from Tubocapsicum anomalum , AC was capable of inducing autophagy and ferroptosis and could induce autophagy-dependent FTH deposition by ubiquitinating GPX4 (56)

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J Med Chem 58(18):73707380