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Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

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Lillys one-of-a-kind Phase 3 ATTAIN-MAINTAIN trial showed that orforglipron helped patients maintain weight loss after transitioning off injectable therapies, positioning it for longer-term use rather than induction

For example, older mice given nightly melatonin had levels of oxidative damage markers in brain and liver comparable to much younger mice, and they maintained better learning/memory performance than unsupplemented old mice (Jia et al., 2024