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These mechanisms may interact at the ovary and endometrium, with downstream implications for oocyte competence, endometrial receptivity, and pregnancy outcomes

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These factors include increased accumulation of advanced glycation end products (AGEs), chronic inflammation due to increased proinflammatory cytokines, and bone microvascular lesions with decreased vascular flow and increased bone fragility

10.3390/ijms19113447 Int

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modulation of transforming growth factor beta (TGF-)