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Furthermore, a pooled analysis of four trials showed that tolerability improved over time, demonstrating that sensitivity to gastrointestinal AEs decreased with prolonged exposure (17)

[5] Rest in a quiet, darkened environment can significantly alleviate headache intensity

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Vilsbll T, Bain SC, Leiter LA, Lingvay I, Matthews D, Sim R, et al

il primo trial formale di switch iniettabile orale nella classe, e conferma due cose insieme: che il passaggio alla pillola praticabile senza sacrificare i risultati raggiunti, e che la terapia farmacologica dellobesit per sua natura cronica, perch senza il farmaco il peso torna rapidamente