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A 2025 Bayesian network meta-analysis reported that 10.6% of patients experienced diarrhea while using semaglutide, according to Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes

Before starting Wegovy: Discuss your complete medical history with your prescriber, including all episodes of diverticulitis, their severity, and any complications Ensure diverticulitis is in remission with no active inflammation or symptoms Review current medications , particularly those with a narrow therapeutic index (e.g., warfarin may require more frequent INR monitoring initially due to Wegovy's effect on gastric emptying) Understand the side effect profile and how to distinguish between expected medication effects and potential diverticulitis symptoms During treatment: Maintain adequate hydration , particularly important given the gastrointestinal side effects and for bowel health Follow dietary advice for both weight management and diverticular disease management, ensuring adequate fibre intake once acute episodes have resolved (a temporary low-fibre diet may be advised during flares) Monitor bowel habits carefully and report significant changes to your healthcare provider Keep a symptom diary during the initial weeks to track gastrointestinal symptoms Attend regular follow-up appointments to assess treatment response and tolerability NICE guidance on obesity management (CG189) recommends that pharmacological treatment should be part of a comprehensive approach including dietary modification, physical activity, and behavioural interventions

Exp Ther Med (2021) 21:72

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